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until superiority for patient-oriented outcomes is shown in comparative trials with allopurinol, febuxostat should be reserved for symptomatic patients who do not obtain adequate reduction in serum uric acid levels or are intolerant of allopurinol.

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absolute bioavailability when receiving 100 mg of allopurinol was 67 , while taking allopurinol 300 mg – 90 .

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