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11 May

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Atypical antipsychotic drugs, including clozaril have been associated with metabolic changes that can increase cardiovascular and cerebrovascular risk.

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do not suddenly stop taking clozaril without first checking with your doctor.

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caution them about driving and any other potentially hazardous activity while taking clozaril see warnings and precautions .

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, cimetidine, escitalopram, erythromycin, paroxetine, bupropion, fluoxetine, quinidine, duloxetine, terbinafine, or sertraline can increase clozaril levels and lead to adverse reactions.

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use caution when administering clozaril to patients with a history of seizures or other predisposing risk factors for seizure e.

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