Cisplatin moderate cisplatin can delay the renal clearance of methotrexate.
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however, no formal drug interaction studies of methotrexate with ppis have been conducted.
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in addition, methotrexate causes, embryotoxicity, abortion and foetal defects in humans.
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naproxen, naproxen sodium and other nonsteroidal anti-inflammatory drugs have been reported to reduce the tubular secretion of methotrexate in an animal model.
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read the patient information leaflet if available from your pharmacist before you start using methotrexate and each time you get a refill.
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women who can become pregnant should have a pregnancy test before starting methotrexate tablets.
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