However, rhabdomyolysis has been reported with zetia monotherapy and with the addition of zetia to agents known to be associated with increased risk of rhabdomyolysis, such as fibrates.
Drug interactions are avoided, due to the zetia could be marketed.
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Excluding the one subject receiving ldl apheresis, zetia significantly lowered plasma sitosterol and campesterol, by 21 and 24 from baseline, respectively.
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More than 25,000 people are in studies testing zetia now, and independent monitors have found no problems that would lead them to stop the trials.
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zetia and any statin or fibrate that the patient is taking concomitantly should be immediately discontinued if myopathy is diagnosed or suspected.