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8 mcg ml; clindamycin has potential to cause adverse effects on breastfed infant s gastrointestinal flora; if oral or intravenous clindamycin is required by nursing mother, it is not a reason to discontinue breastfeeding, but alternate drug may be preferred; monitor infant for possible adverse effects on gastrointestinal flora, such as diarrhea, candidiasis thrush, diaper rash or rarely, blood in stool indicating possible antibiotic-associated colitis.
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in general, if clinical suspicion suggests a toxic shock syndrome but empiric broad spectrum coverage is desired, clindamycin or linezolid should be used early in the course.
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in those who had no previous antibiotics, clindamycin-containing regimens were associated with a 30-day c difficile acquisition rate of 31 versus 0 for the amikacin metronidazole regimen.
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symptoms of a clindamycin overdose include vomiting, appetite loss, weight loss, depression, behavior changes or seizures.
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