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there was more than one study comparing co-trimoxazole with amoxycillin, oral amoxycillin with injectable penicillin ampicillin and chloramphenicol with ampicillin penicillin and studies were of good quality, suggesting the evidence for these comparisons was of high quality compared to other comparisons.
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cefixime is active in vitro against strains of salmonella typhi resistant to ampicillin, chloramphenicol, and or co-trimoxazole.
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no studies were retrieved on cotrimoxazole as a first-line treatment for children with sam.
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moreover, since 1968, the combination of trimethoprim and sulfamethoxazole called co-trimoxazole has been used extensively because a combination of both drugs at certain concentrations has a synergetic bactericidal effect, it reduces selection of ar to either drug and associated costs roberts, 2002; grape, 2006 .
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