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because of its profound and long lasting inhibition of gastric acid secretion, it is theoretically possible that omeprazole may interfere with absorption of drugs where gastric ph is an important determinant of their bioavailability eg, ketoconazole, ampicillin esters, and iron salts .
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ampicillin, azole antifungals, and iron supplements are all absorbed by stomach acids, and in case you are using one of these, your doctor should know about it.
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