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because of its profound and long lasting inhibition of gastric acid secretion, it is theoretically possible that omeprazole may interfere with absorption of drugs where gastric ph is an important determinant of their bioavailability eg, ketoconazole, ampicillin esters, and iron salts .

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our inclusion criteria were as follows i any study type that reported patient outcomes except single case reports; ii for clinical studies, only children under 12 years of age, and for pharmacokinetic studies, adults as well; iii as antibiotics, amoxicillin, ampicillin, cotrimoxazole, gentamicin, penicillin g, chloramphenicol, ceftriaxone and ciprofloxacin; as a control in controlled trials, placebo or active treatment; as predefined outcomes, death, recovery, weight gain, prevention of septic shock and adverse events.

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ampicillin, azole antifungals, and iron supplements are all absorbed by stomach acids, and in case you are using one of these, your doctor should know about it.

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