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11 May

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But after nearly a decade as the top-selling drug, lipitor is set to be toppled in 2012 after getting its first generic rivals four weeks ago.

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in this double-blind, placebo-controlled study, patients were treated with anti-hypertensive therapy goal bp 140 90 mm hg for non-diabetic patients; 130 80 mm hg for diabetic patients and allocated to either lipitor 10 mg daily n 5168 or placebo n 5137 , using a covariate adaptive method which took into account the distribution of nine baseline characteristics of patients already enrolled and minimized the imbalance of those characteristics across the groups.

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after six months on a low dose of 20 mg of lipitor a day, two-thirds of the patients had abnormalities in the heart s filling phase, when the muscle fills with blood.

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one key lesson to be learned from lipitor s success is the clear benefit of using modular approaches in portfolio management.

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lipitor therapy should be temporarily withheld or discontinued in any patient with an acute, serious condition suggestive of a myopathy or having a risk factor predisposing to the development of renal failure secondary to rhabdomyolysis e.


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