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In controlled clinical trials of metformin of 29 weeks duration, a decrease to subnormal levels of previously normal serum vitamin b 12 levels, without clinical manifestations, was observed in approximately 7 of patients.

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some positives of metformin include note, its not all women who take metformin should experience these benefits, everyone reacts differently towards medication .

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some patients have experienced the following side effects while taking sitagliptin in combination with insulin with or without metformin .

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here we report that the biguanide metformin prevents brca1 haploinsufficiency-driven rankl gene overexpression, thereby disrupting an auto-regulatory feedback control of rankl-addicted cancer stem cell-like states within brca1mut – cell populations.

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metformin helps prevent the cardiovascular complications of diabetes, and somewhat lowers ldl tg.

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