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Be sure to mention any of the following certain antibiotics, including ampicillin principen, in unasyn ;anticoagulants blood thinners such as warfarin coumadin ; atazanavir reyataz ; benzodiazepines such as diazepam valium ; cilostazol pletal ; clopidogrel plavix ; cyclosporine neoral, sandimmune ; digoxin lanoxicaps, lanoxin disulfiram antabuse ; diuretics water pills ; iron supplements; ketoconazole nizoral ; methotrexate rheumatrex, trexall , nelfinavir viracept ; phenytoin dilantin ; saquinavir invirase ; tacrolimus prograf ; and voriconazole vfend and other prescription antifungal or anti-yeast medications.

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of the 736 patients who completed 52 weeks of treatment in study trial 3, 612 83 entered the double-blind, 1-year extension study 292 leflunomide, 320 methotrexate .

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caution should be used when nsaids and salicylates are administered concomitantly with methotrexate.

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people taking methotrexate usually feel improvements in 3-6 weeks, but it can take up to 3 months to feel the full benefit of the drug.

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