See precautions; organ system toxicity hepatic methotrexate-induced lung disease is a potentially dangerous lesion, which may occur acutely at any time during therapy and which has been reported at doses as low as 7.
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sarah i had a lot of side effects and felt worn down from the once weekly dosage in which methotrexate is given.
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comparable results to leflunomide were observed in patients taking sulphasalazine and methotrexate.
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methotrexate is also indicated in the treatment of meningeal leukemia.
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at high doses, methotrexate by injection may also be safer for the liver because it is absorbed and distributed through the circulation before it reaches the liver, whereas pills are digested, enter the circulation through blood vessels draining the stomach and intestines and then go directly to the liver.
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