Bupropion lowers the threshold for epileptic seizures, 67 and therefore can potentially interact with other medications that also lower it, such as carbapenems, cholinergic agents, fluoroquinolones, interferons, chloroquine, mefloquine, lindane, theophylline, systemic corticosteroids e.
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this may be of clinical importance because their plasma concentrations are as high or higher than those of bupropion.
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absorption following oral administration of wellbutrin xl to healthy volunteers, time to peak plasma concentrations for bupropion was approximately 5 hours and food did not affect the c max or auc of bupropion.
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