Of these, 48 cases were fatal and, of the fatalities, 17 appeared to involve paroxetine alone.
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when a single oral 30-mg dose of immediate-release paroxetine was administered at phenytoin steady state 300 mg once daily for 14 days , paroxetine auc and t were reduced by an average of 50 and 35 , respectively compared to immediate-release paroxetine administered alone.
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when a single oral 30-mg dose of paxil was administered at phenobarbital steady state 100 mg once daily for 14 days , paroxetine auc and t were reduced by an average of 25 and 38 , respectively compared to paroxetine administered alone.
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